Long-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury in aging mouse model.

ABSTRACT:

Background

Age-related changes in the cerebrovasculature, including blood-brain barrier (BBB) disruption and vascular dementia, are emerging as potential risks for many neurodegenerative diseases. Therefore, the endothelial cells that constitute the cerebrovasculature may play key roles in preventing brain injury. Our previous study showed that CU06-1004, an endothelial cell dysfunction blocker, prevented vascular leakage, enhanced vascular integrity in ischemic reperfusion injury, and promoted the normalization of tumor vasculature. Here, we evaluated the effects of CU06-1004 on age-related cerebrovascular functional decline in the aged mouse brain.

Results

In this study, we investigated the protective effects of CU06-1004 against oxidative stress-induced damage in human br

SUBMITTER: Kim H 

PROVIDER: S-EPMC9893613 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature