Organization of self-advantageous niche by neural stem/progenitor cells during development via autocrine VEGF-A under hypoxia.

ABSTRACT:

Background

Tissue stem cells are confined within a special microenvironment called niche. Stem cells in such a niche are supplied with nutrients and contacted by other cells to maintain their characters and also to keep or expand their population size. Besides, oxygen concentration is a key factor for stem cell niche. Adult neural stem/progenitor cells (NSPCs) are known to reside in a hypoxic niche. Oxygen concentration levels are lower in fetal organs including brain than maternal organs. However, how fetal NSPCs adapt to the hypoxic environment during brain development, particularly before pial and periventricular vessels start to invade the telencephalon, has not fully been elucidated.

Methods

NSPCs were prepared from cerebral cortices of embryonic day (E) 11.5 or E14.5 m

SUBMITTER: Kashiwagi T 

PROVIDER: S-EPMC9893632 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature