Overview of microbial profiles in human hepatocellular carcinoma and adjacent nontumor tissues.

ABSTRACT:

Background

Intratumoral microbial communities have been recently discovered to exist in a variety of cancers and have been found to be intricately involved in tumour progression. Therefore, investigating the profiles and functions of intratumoral microbial distribution in hepatocellular carcinoma (HCC) is imperative.

Methods

To verify the presence of microorganisms in HCC, we performed fluorescence in situ hybridization (FISH) using HCC tissues and conducted MiSeq using 99 HCC and paracancerous tissues to identify the key microorganisms and changes in metabolic pathways affecting HCC progression through a variety of bioinformatics methods.

Results

Microbial diversity was significantly higher in HCC tissues than in adjacent tissues. The abundances of microorganisms suc

SUBMITTER: He Y 

PROVIDER: S-EPMC9893660 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature