Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality.

ABSTRACT:

Background

Extensive evidence links higher body mass index (BMI) to higher odds of depression in people of European ancestry. However, our understanding of the relationship across different settings and ancestries is limited. Here, we test the relationship between body composition and depression in people of East Asian ancestry.

Methods

Multiple Mendelian randomisation (MR) methods were used to test the relationship between (a) BMI and (b) waist-hip ratio (WHR) with depression. Firstly, we performed two-sample MR using genetic summary statistics from a recent genome-wide association study (GWAS) of depression (with 15,771 cases and 178,777 controls) in people of East Asian ancestry. We selected 838 single nucleotide polymorphisms (SNPs) correlated with BMI and 263 SNPs corre

SUBMITTER: O'Loughlin J 

PROVIDER: S-EPMC9893684 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature