Gene expression profiles and bioinformatics analysis in lung samples from ovalbumin-induced asthmatic mice.

ABSTRACT:

Background

Asthma is characterized by chronic inflammation and airway remodeling. However, limited study is conducted on the gene expression profiles of ovalbumin (OVA) induced asthma in mice. Here, we explored the gene expression profiles in lung tissues from mice with OVA-induced asthma using microarray and bioinformatics analysis.

Methods

For establishment of OVA-induced asthma model, mice first received intraperitoneal sensitization with OVA on day 0, 7 and 14, followed by atomizing inhalation of OVA 3 times a week for 8 weeks. The lung tissues were collected and subjected to microarray analysis, bioinformatics analysis and expression validation.

Results

Microarray data of lung tissues suggested that 3754 lncRNAs and 2976 mRNAs were differentially expressed in lun

SUBMITTER: Song Y 

PROVIDER: S-EPMC9893693 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature