Hippocampus-centred grey matter covariance networks predict the development and reversion of mild cognitive impairment.

ABSTRACT: Mild cognitive impairment (MCI) has been thought of as the transitional stage between normal ageing and Alzheimer's disease, involving substantial changes in brain grey matter structures. As most previous studies have focused on single regions (e.g. the hippocampus) and their changes during MCI development and reversion, the relationship between grey matter covariance among distributed brain regions and clinical development and reversion of MCI remains unclear. With samples from two independent studies (155 from the Beijing Aging Brain Rejuvenation Initiative and 286 from the Alzheimer's Disease Neuroimaging Initiative), grey matter covariance of default, frontoparietal, and hippocampal networks were identified by seed-based partial least square analyses, and random forest models were appl

SUBMITTER: Dang M 

PROVIDER: S-EPMC9893696 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature