In-line monitoring of protein concentration with MIR spectroscopy during UFDF.

ABSTRACT: Rapid increase of product titers in upstream processes has presented challenges for downstream processing, where purification costs increase linearly with the increase of the product yield. Hence, innovative solutions are becoming increasingly popular. Process Analytical Technology (PAT) tools, such as spectroscopic techniques, are on the rise due to their capacity to provide real-time, precise analytics. This ensures consistent product quality and increased process understanding, as well as process control. Mid-infrared spectroscopy (MIR) has emerged as a highly promising technique within recent years, owing to its ability to monitor several critical process parameters at the same time and unchallenging spectral analysis and data interpretation. For in-line monitoring, Attenuated Total Re

SUBMITTER: Milewska A 

PROVIDER: S-EPMC9893749 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature