Exploring causal correlations between inflammatory cytokines and systemic lupus erythematosus: A Mendelian randomization.

ABSTRACT:

Objectives

Previous studies have reported that a few inflammatory cytokines have associations with systemic lupus erythematosus (SLE)-for example, IL-6, IL-17, and macrophage inflammatory protein (MIP). This Mendelian randomization was conducted to further assess the causal correlations between 41 inflammatory cytokines and SLE.

Methods

The two-sample Mendelian randomization utilized genetic variances of SLE from a large publicly available genome-wide association study (GWAS) (7,219 cases and 15,991 controls of European ancestry) and inflammatory cytokines from a GWAS summary containing 8,293 healthy participants. Causalities of exposures and outcomes were explored mainly using inverse variance weighted method. In addition, multiple sensitivity analyses including MR-Egger, w

SUBMITTER: Xiang M 

PROVIDER: S-EPMC9893779 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature