Systemic review of genetic and epigenetic factors underlying differential toxicity to environmental lead (Pb) exposure.

ABSTRACT: Lead (Pb) poisoning is a major public health concern in environmental justice communities of the USA and in many developing countries. There is no identified safety threshold for lead in blood, as low-level Pb exposures can lead to severe toxicity in highly susceptible individuals and late onset of diseases from early-life exposure. However, identifying "susceptibility genes" or "early exposure biomarkers" remains challenging in human populations. There is a considerable variation in susceptibility to harmful effects from Pb exposure in the general population, likely due to the complex interplay of genetic and/or epigenetic factors. This systematic review summarizes current state of knowledge on the role of genetic and epigenetic factors in determining individual susceptibility in response

SUBMITTER: Cuomo D 

PROVIDER: S-EPMC9893814 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature