Multimodal single-cell analyses of peripheral blood mononuclear cells of COVID-19 patients in Japan.

ABSTRACT: SARS-CoV-2 continues to spread worldwide. Patients with COVID-19 show distinct clinical symptoms. Although many studies have reported various causes for the diversity of symptoms, the underlying mechanisms are not fully understood. Peripheral blood mononuclear cells from COVID-19 patients were collected longitudinally, and single-cell transcriptome and T cell receptor repertoire analysis was performed. Comparison of molecular features and patients' clinical information revealed that the proportions of cells present, and gene expression profiles differed significantly between mild and severe cases; although even among severe cases, substantial differences were observed among the patients. In one severely-infected elderly patient, an effective antibody response seemed to have failed, which m

SUBMITTER: Kashima Y 

PROVIDER: S-EPMC9893982 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature