Association between ten-eleven methylcytosine dioxygenase 2 genetic variation and viral load in people with HIV.

ABSTRACT:

Introduction

Identifying genetic factors that influence HIV-pathogenesis is critical for understanding disease pathways. Previous studies have suggested a role for the human gene ten-eleven methylcytosine dioxygenase 2 (TET2) in modulating HIV-pathogenesis.

Methods

We assessed whether genetic variation in TET2 was associated with markers of HIV-pathogenesis using both gene level and single nucleotide polymorphism (SNP) level association in 8512 HIV-positive persons across five clinical trial cohorts.

Results

Variation at both the gene and SNP-level of TET2 was found to be associated with levels of HIV viral load (HIV-VL) consistently in the two cohorts that recruited antiretroviral-naïve participants. The SNPs occurred in two clusters of high linkage disequilibrium (L

SUBMITTER: Murray DD 

PROVIDER: S-EPMC9894145 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature