Association between renal sympathetic denervation and arterial stiffness: the ASORAS study.

ABSTRACT:

Objectives

Renal sympathetic denervation (RDN) reduces blood pressure (BP). However, one out of three patients does not exhibit a significant BP response to the therapy. This study investigates the association between noninvasive vascular stiffness indices and RDN-mediated BP reduction.

Methods

In this prospective, single-arm pilot study, patients with systolic office BP at least 140 mmHg, mean 24-h systolic ambulatory blood pressure (ABP) at least 130 mmHg and at least three prescribed antihypertensive drugs underwent radiofrequency RDN. The primary efficacy endpoint was temporal evolution of mean 24-h systolic ABP throughout 1-year post RDN (measured at baseline and 3-6-12 months). Effect modification was studied for baseline ultrasound carotid-femoral and magnetic resonan

SUBMITTER: Zeijen VJM 

PROVIDER: S-EPMC9894147 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature