Associations of polygenic risk scores for preeclampsia and blood pressure with hypertensive disorders of pregnancy.

ABSTRACT:

Background

Preexisting hypertension increases risk for preeclampsia. We examined whether a generic blood pressure polygenic risk score (BP-PRS), compared with a preeclampsia-specific polygenic risk score (PE-PRS), could better predict hypertensive disorders of pregnancy.

Methods

Our study sample included 141 298 genotyped FinnGen study participants with at least one childbirth and followed from 1969 to 2021. We calculated PRSs for SBP and preeclampsia using summary statistics for greater than 1.1 million single nucleotide polymorphisms.

Results

We observed 8488 cases of gestational hypertension (GHT) and 6643 cases of preeclampsia. BP-PRS was associated with GHT [multivariable-adjusted hazard ratio for 1SD increase in PRS (hazard ratio 1.38; 95% CI 1.35-1.41)] and pre

SUBMITTER: Nurkkala J 

PROVIDER: S-EPMC9894151 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature