Human cytomegalovirus induces neuronal enolase to support virally mediated metabolic remodeling.

ABSTRACT: Viruses depend on cellular metabolic resources to supply the energy and biomolecular building blocks necessary for their replication. Human cytomegalovirus (HCMV), a leading cause of birth defects and morbidity in immunosuppressed individuals, induces numerous metabolic activities that are important for productive infection. However, many of the mechanisms through which these metabolic activities are induced and how they contribute to infection are unclear. We find that HCMV infection of fibroblasts induces a neuronal gene signature as well as the expression of several metabolic enzyme isoforms that are typically expressed in other tissue types. Of these, the most substantially induced glycolytic gene was the neuron-specific isoform of enolase 2 (ENO2). Induction of ENO2 expression is impo

SUBMITTER: Moreno I 

PROVIDER: S-EPMC9894225 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature