Highly efficient reprogrammable mouse lines with integrated reporters to track the route to pluripotency.

ABSTRACT: Revealing the molecular events associated with reprogramming different somatic cell types to pluripotency is critical for understanding the characteristics of induced pluripotent stem cell (iPSC) therapeutic derivatives. Inducible reprogramming factor transgenic cells or animals-designated as secondary (2°) reprogramming systems-not only provide excellent experimental tools for such studies but also offer a strategy to study the variances in cellular reprogramming outcomes due to different in vitro and in vivo environments. To make such studies less cumbersome, it is desirable to have a variety of efficient reprogrammable mouse systems to induce successful mass reprogramming in somatic cell types. Here, we report the development of two transgenic mouse lines from which 2° cells reprogram w

SUBMITTER: Elbaz J 

PROVIDER: S-EPMC9894234 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature