FoxO induces pupal diapause by decreasing TGFβ signaling.

ABSTRACT: Diapause is a form of dormancy used widely by insects to survive adverse seasons. Previous studies have demonstrated that forkhead box O (FoxO) is activated during pupal diapause initiation in the moth Helicoverpa armigera. However, it is unclear how FoxO induces diapause. Here, we show that knockout of FoxO causes H. armigera diapause-destined pupae to channel into nondiapause, indicating that FoxO is a master regulator that induces insect diapause. FoxO activates the ubiquitin-proteasome system (UPS) by promoting ubiquitin c (Ubc) expression via directly binding to the Ubc promoter. Activated UPS decreases transforming growth factor beta (TGFβ) receptor signaling via ubiquitination to block developmental signaling to induce diapause. This study significantly a

SUBMITTER: Zhang XS 

PROVIDER: S-EPMC9894235 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature