Reformulated McNamara RBE-weighted beam orientation optimization for intensity modulated proton therapy.

ABSTRACT:

Purpose

Empirical relative biological effectiveness (RBE) models have been used to estimate the biological dose in proton therapy but do not adequately capture the factors influencing RBE values for treatment planning. We reformulate the McNamara RBE model such that it can be added as a linear biological dose fidelity term within our previously developed sensitivity-regularized and heterogeneity-weighted beam orientation optimization (SHBOO) framework.

Methods

Based on our SHBOO framework, we formulated the biological optimization problem to minimize total McNamara RBE dose to OARs. We solve this problem using two optimization algorithms: FISTA (McNam-FISTA) and Chambolle-Pock (McNam-CP). We compare their performances with a physical dose optimizer assuming RBE = 1.1 in all

SUBMITTER: Ramesh P 

PROVIDER: S-EPMC9894336 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature