Biomechanics of keratoconus: Two numerical studies.

ABSTRACT:

Background

The steep cornea in keratoconus can greatly impair eyesight. The etiology of keratoconus remains unclear but early injury that weakens the corneal stromal architecture has been implicated. To explore keratoconus mechanics, we conducted two numerical simulation studies.

Methods

A finite-element model describing the five corneal layers and the heterogeneous mechanical behaviors of the ground substance and lamellar collagen-fiber architecture in the anterior and posterior stroma was developed using the Holzapfel-Gasser-Ogden constitutive model. The geometry was from a healthy subject. Its stroma was divided into anterior, middle, and posterior layers to assess the effect of changing regional mechanical parameters on corneal displacement and maximum principal stress u

SUBMITTER: Falgayrettes N 

PROVIDER: S-EPMC9894483 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature