Modelling ribosome kinetics and translational control on dynamic mRNA.

ABSTRACT: The control of protein synthesis and the overall levels of various proteins in the cell is critical for achieving homoeostasis. Regulation of protein levels can occur at the transcriptional level, where the total number of messenger RNAs in the overall transcriptome are controlled, or at the translational level, where interactions of proteins and ribosomes with the messenger RNA determine protein translational efficiency. Although transcriptional control of mRNA levels is the most commonly used regulatory control mechanism in cells, positive-sense single-stranded RNA viruses often utilise translational control mechanisms to regulate their proteins in the host cell. Here I detail a computational method for stochastically simulating protein synthesis on a dynamic messenger RNA using the Gill

SUBMITTER: Dykeman EC 

PROVIDER: S-EPMC9894550 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature