The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D.

ABSTRACT: RNA recombination in positive-strand RNA viruses is a molecular-genetic process, which permits the greatest evolution of the genome and may be essential to stabilizing the genome from the deleterious consequences of accumulated mutations. Enteroviruses represent a useful system to elucidate the details of this process. On the biochemical level, it is known that RNA recombination is catalyzed by the viral RNA-dependent RNA polymerase using a template-switching mechanism. For this mechanism to function in cells, the recombining genomes must be located in the same subcellular compartment. How a viral genome is trafficked to the site of genome replication and recombination, which is membrane associated and isolated from the cytoplasm, is not known. We hypothesized that genome translation was e

SUBMITTER: Kim H 

PROVIDER: S-EPMC9894558 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature