Chronic Liver Disease and Cirrhosis are Associated with Worse Outcomes Following SARS-CoV-2 Infection.

ABSTRACT:

Background and aims

Studies evaluating the impact of SARS-CoV-2 on chronic liver disease (CLD) are limited and have focused mostly on hospitalized patients or those with cirrhosis. We aim to evaluate the impact of underlying CLD on patient outcomes following COVID-19 using a one of the largest COVID-19+CLD cohorts to date.

Methods

Data from the COVID-19 Research Database (https://covid19researchdatabase.org) were evaluated from 4/1/2020-8/31/2021 to determine whether concurrent CLD was associated with worse outcomes within 30-days of COVID-19 diagnosis, including need for hospitalization, pneumonia, severe pneumonia, respiratory failure, and multi-organ failure. Among patients with COVID-19+CLD, risks of liver decompensation and acute on chronic liver failure (ACLF) were eva

SUBMITTER: Wong RJ 

PROVIDER: S-EPMC9894759 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature