Are serum levels of inflammatory markers associated with the severity of symptoms of bipolar disorder?

ABSTRACT:

Background

To explore the relationship between serum levels of inflammatory markers and symptomatic severity of bipolar disorder (BD).

Materials and methods

A cross-sectional study was conducted on 126 BD patients with current depressive episode (BDD), 102 BD patients with current mixed or (hypo)manic episode (BDM) and 94 healthy controls (HC). All participants were drug-naïve and had no current active physical illness associated with inflammatory response or history of substance abuse. Fasting serum levels of CRP, leptin (LEP), adiponectin (ADP), visfatin (VIS), TNF-α, IL-2, IL-6, IL-10, IL-17), and monocyte chemoattractant protein-1 (MCP-1) were measured with enzyme-linked immunosorbent assay (ELISA). Symptomatic severity of BD was assessed with HAMD-17 and YMRS. Generaliz

SUBMITTER: Wu X 

PROVIDER: S-EPMC9894870 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature