Polygenic risk scores and kidney traits in the Hispanic/Latino population: The Hispanic Community Health Study/Study of Latinos.

ABSTRACT: Estimated glomerular filtration rate (eGFR) is used to evaluate kidney function and determine the presence of chronic kidney disease (CKD), a highly prevalent disease in the US^{1 , 2 , 3} that varies among subgroups of Hispanic/Latino individuals.^{4 , 5} The polygenic risk score (PRS) is a popular method that uses large genome-wide association studies (GWASs) to provide a strong estimate of disease risk.⁷ However, due to the limited availability of summary statistics from GWAS meta-analyses based on Hispanic/Latino populations, PRSs can only be computed using different ancestry GWASs. The performance of eGFR PRSs derived from other GWAS reference populations for Hispanic/Latino population has not

SUBMITTER: Zhou LY 

PROVIDER: S-EPMC9894917 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature