The human microbial exposome: expanding the Exposome-Explorer database with gut microbial metabolites.

ABSTRACT: Metabolites produced by the gut microbiota play an important role in the cross-talk with the human host. Many microbial metabolites are biologically active and can pass the gut barrier and make it into the systemic circulation, where they form the gut microbial exposome, i.e. the totality of gut microbial metabolites in body fluids or tissues of the host. A major difficulty faced when studying the microbial exposome and its role in health and diseases is to differentiate metabolites solely or partially derived from microbial metabolism from those produced by the host or coming from the diet. Our objective was to collect data from the scientific literature and build a database on gut microbial metabolites and on evidence of their microbial origin. Three types of evidence on the microbial or

SUBMITTER: Neveu V 

PROVIDER: S-EPMC9894932 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature