Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1.

ABSTRACT: As a terpenoids natural product isolated from the plant Thunder God Vine, Celastrol is widely studied for its pharmacological activities, including anti-tumor activities. The clinical application of Celastrol is strictly limited due to its severe side effects, whereas previously revealed targets and mechanism of Celastrol seldom reduce its in vivo toxicity via structural optimization. Target identification has a far-reaching influence on the development of innovative drugs, and omics data has been widely used for unbiased target prediction. However, it is difficult to enrich target of specific phenotype from thousands of genes or proteins, especially for natural products with broad promising activities. Here, we developed a text-mining-based web-server tool to enrich targets from omics dat

SUBMITTER: Xu H 

PROVIDER: S-EPMC9895061 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature