Non-canonical functions of spliceosome components in cancer progression.

ABSTRACT: Dysregulation of pre-mRNA splicing is a common hallmark of cancer cells and it is associated with altered expression, localization, and mutations of the components of the splicing machinery. In the last few years, it has been elucidated that spliceosome components can also influence cellular processes in a splicing-independent manner. Here, we analyze open source data to understand the effect of the knockdown of splicing factors in human cells on the expression and splicing of genes relevant to cell proliferation, migration, cell cycle regulation, DNA repair, and cell death. We supplement this information with a comprehensive literature review of non-canonical functions of splicing factors linked to cancer progression. We also specifically discuss the involvement of splicing factors in int

SUBMITTER: Ivanova OM 

PROVIDER: S-EPMC9895063 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature