Lower gut dysbiosis and mortality in acute critical illness: a systematic review and meta-analysis.

ABSTRACT:

Background

The human gastrointestinal tract harbours a complex multi-kingdom community known as the microbiome. Dysbiosis refers to its disruption and is reportedly extreme in acute critical illness yet its clinical implications are unresolved. The review systematically evaluates the association between gut dysbiosis and clinical outcomes of patients early in critical illness.

Methods

Following PRISMA guidelines, a prospectively registered search was undertaken of MEDLINE and Cochrane databases for observational studies undertaking metagenomic sequencing of the lower gastrointestinal tract of critically ill adults and children within 72 h of admission. Eligible studies reported an alpha diversity metric and one or more of the primary outcome, in-hospital mortality, or second

SUBMITTER: Evans T 

PROVIDER: S-EPMC9895325 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature