Association between growth differentiation factor 15 levels and gestational diabetes mellitus: A combined analysis.

ABSTRACT:

Objective

Gestational diabetes mellitus (GDM) is a common glucose metabolism disease occurs in pregnancy that affects both maternal and neonatal health. Recently, increasing studies have attached importance to the relationship between growth differentiation factor 15 (GDF-15) and GDM, but the results were inconclusive. Therefore, we conducted a meta-analysis to examine the association between GDF-15 and GDM.

Materials and methods

A systematical search was performed in Gene Expression Omnibus (GEO), PubMed and Google Scholar till Oct 27, 2022. We first calculated the mean and standard deviation of GDF-15 expression levels from the included eligible datasets and articles. Then, a meta-analysis was conducted to depict the difference in GDF-15 mRNA or GDF-15 protein expre

SUBMITTER: Lu YC 

PROVIDER: S-EPMC9895392 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature