Altered distribution and localization of organellar Na⁺/H⁺ exchangers in postmortem schizophrenia dorsolateral prefrontal cortex.

ABSTRACT: Schizophrenia is a complex and multifactorial disorder associated with altered neurotransmission as well as numerous signaling pathway and protein trafficking disruptions. The pH of intracellular organelles involved in protein trafficking is tightly regulated and impacts their functioning. The SLC9A family of Na⁺/H⁺ exchangers (NHEs) plays a fundamental role in cellular and intracellular pH homeostasis. Four organellar NHE isoforms (NHE6-NHE9) are targeted to intracellular organelles involved in protein trafficking. Increased interactions between organellar NHEs and receptor of activated protein C kinase 1 (RACK1) can lead to redistribution of NHEs to the plasma membrane and hyperacidification of target organelles. Given their role in organelle pH regulation, altered

SUBMITTER: Pruett BS 

PROVIDER: S-EPMC9895429 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature