Prostate Cancer Tumor Volume and Genomic Risk

ABSTRACT: Take Home Message Higher tumor volume was associated with worse genomic features in intermediate- and high-risk disease, but not in low-risk prostate cancer. These results encourage utilization of active surveillance in the majority of low-risk patients with a high tumor burden.

Background

Despite the historic association of higher prostate cancer volume with worse oncologic outcomes, little is known about the impact of tumor volume on cancer biology.

Objective

To characterize the relationship between tumor volume (measured by percent positive cores [PPC]) and cancer biology (measured by Decipher genomic risk classifier [GC]) in men who underwent prostate biopsy.

Design, setting, and participants

Prostate biopsies from 52 272 men profiled with Decipher captured i

SUBMITTER: Ramaswamy A 

PROVIDER: S-EPMC9895765 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature