Metabolome-Wide Reprogramming Modulated by Wnt/β-Catenin Signaling Pathway.

ABSTRACT: A family of signal transduction pathways known as wingless type (Wnt) signaling pathways is essential to developmental processes like cell division and proliferation. Mutation in Wnt signaling results in a variety of diseases, including cancers of the breast, colon, and skin, metabolic disease, and neurodegenerative disease; thus, the Wnt signaling pathways have been attractive targets for disease treatment. However, the complicatedness and large involveness of the pathway often hampers pinpointing the specific targets of the metabolic process. In our current study, we investigated the differential metabolic regulation by the overexpression of the Wnt signaling pathway in a timely-resolved manner by applying high-throughput and un-targeted metabolite profiling. We have detected and annotat

SUBMITTER: Park SJ 

PROVIDER: S-EPMC9895996 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature