Clinical Importance of Clonal Hematopoiesis in Metastatic Gastrointestinal Tract Cancers.

ABSTRACT:

Importance

Clonal hematopoiesis (CH) has been associated with development of atherosclerosis and leukemia and worse survival among patients with cancer; however, the association with cancer therapy efficacy, in particular immune checkpoint blockade (ICB), and toxicity has not yet been established. Given the widespread use of ICB and the critical role hematopoietic stem cell-derived lymphocytes play in mediating antitumor responses, CH may be associated with therapeutic efficacy and hematologic toxicity.

Objective

To determine the association between CH and outcomes, hematologic toxicity, and therapeutic efficacy in patients with metastatic gastrointestinal tract cancers being treated with systemic therapy, both in the first-line metastatic treatment setting and in ICB.

De

SUBMITTER: Diplas BH 

PROVIDER: S-EPMC9896303 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature