Cardiovascular Magnetic Resonance Imaging in Patients With Ibrutinib-Associated Cardiotoxicity.

ABSTRACT:

Importance

Ibrutinib has been associated with serious cardiotoxic arrhythmias. In preclinical models, these events are paralleled or proceeded by diffuse myocardial injury (inflammation and fibrosis). Yet whether this is seen in patients or has implications for future cardiotoxic risk is unknown.

Objective

To assess the incidence and outcomes of myocardial injury among patients with ibrutinib-related cardiotoxicity.

Design, setting, and participants

This cohort study included consecutive patients treated with ibrutinib from 2012 to 2019, phenotyped using cardiovascular magnetic resonance (CMR) from a large US Comprehensive Cancer Center registry.

Exposures

Ibrutinib treatment for cancer control.

Main outcomes and measures

The primary outcome was the pres

SUBMITTER: Buck B 

PROVIDER: S-EPMC9896369 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature