Association of Radiation and Procarbazine Dose With Risk of Colorectal Cancer Among Survivors of Hodgkin Lymphoma.

ABSTRACT:

Importance

Hodgkin lymphoma (HL) survivors have higher rates of colorectal cancer, which may be associated with subdiaphragmatic radiation therapy and/or alkylating chemotherapy. Although radiation dose-response associations with breast, lung, stomach, pancreatic, and esophageal cancer after HL have been demonstrated, the association of radiation therapy with colorectal cancer remains unclear.

Objective

To quantify the rate of colorectal cancer according to radiation dose to the large bowel and procarbazine dose among HL survivors.

Design, setting, and participants

A nested case-control study examined 5-year HL survivors at 5 hospital centers in the Netherlands. Participants had been diagnosed with HL in 1964 to 2000, when they were 15 to 50 years of age, and were fol

SUBMITTER: Geurts YM 

PROVIDER: S-EPMC9896374 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature