Motivations, enrollment decisions, and socio-demographic characteristics of healthy volunteers in phase 1 research.

ABSTRACT:

Background/aim

Phase 1 trials with healthy volunteers are an integral step in drug development. Commentators worry about the possible exploitation of healthy volunteers because they are assumed to be disadvantaged, marginalized, and inappropriately influenced by the offer of money for research for which they do not appreciate the inherent risks. Yet there are limited data to support or refute these concerns. This study aims to describe the socio-demographic characteristics, motivations, and enrollment decision-making of a large cohort of healthy volunteers.

Methods

We used a cross-sectional anonymous survey of 1194 healthy volunteers considering enrollment in phase 1 studies at Pfizer Clinical Research Units in New Haven, CT; Brussels, Belgium; and Singapore. Descriptive sta

SUBMITTER: Grady C 

PROVIDER: S-EPMC9896431 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature