Mendelian randomisation identifies priority groups for prophylactic EBV vaccination.

ABSTRACT:

Background

Epstein Barr virus (EBV) infects ~ 95% of the population worldwide and is known to cause adverse health outcomes such as Hodgkin's, non-Hodgkin's lymphomas, and multiple sclerosis. There is substantial interest and investment in developing infection-preventing vaccines for EBV. To effectively deploy such vaccines, it is vital that we understand the risk factors for infection. Why particular individuals do not become infected is currently unknown. The current literature, describes complex, often conflicting webs of intersecting factors-sociodemographic, clinical, genetic, environmental-, rendering causality difficult to decipher. We aimed to use Mendelian randomization (MR) to overcome the issues posed by confounding and reverse causality to determine the causal risk fact

SUBMITTER: Muckian MD 

PROVIDER: S-EPMC9896437 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature