Two Color Imaging of Different Hypoxia Levels in Cancer Cells.

ABSTRACT: Hypoxia (low oxygen levels) occurs in a range of biological contexts, including plants, bacterial biofilms, and solid tumors; it elicits responses from these biological systems that impact their survival. For example, conditions of low oxygen make treating tumors more difficult and have a negative impact on patient prognosis. Therefore, chemical probes that enable the study of biological hypoxia are valuable tools to increase the understanding of disease-related conditions that involve low oxygen levels, ultimately leading to improved diagnosis and treatment. While small-molecule hypoxia-sensing probes exist, the majority of these image only very severe hypoxia (<1% O₂) and therefore do not give a full picture of heterogeneous biological hypoxia. Commonly used antibody-based ima

SUBMITTER: Wallabregue ALD 

PROVIDER: S-EPMC9896549 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature