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Multistate Redox-Switchable Ion Transport Using Chalcogen-Bonding Anionophores.

ABSTRACT: Synthetic supramolecular transmembrane anionophores have emerged as promising anticancer chemotherapeutics. However, key to their targeted application is achieving spatiotemporally controlled activity. Herein, we report a series of chalcogen-bonding diaryl tellurium-based transporters in which their anion binding potency and anionophoric activity are controlled through reversible redox cycling between Te oxidation states. This unprecedented in situ reversible multistate switching allows for switching between ON and OFF anion transport and is crucially achieved with biomimetic chemical redox couples.

SUBMITTER: Docker A

PROVIDER: S-EPMC9896566 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Multistate Redox-Switchable Ion Transport Using Chalcogen-Bonding Anionophores.

Docker Andrew A Johnson Toby G TG Kuhn Heike H Zhang Zongyao Z Langton Matthew J MJ

Journal of the American Chemical Society 20230118 4

Synthetic supramolecular transmembrane anionophores have emerged as promising anticancer chemotherapeutics. However, key to their targeted application is achieving spatiotemporally controlled activity. Herein, we report a series of chalcogen-bonding diaryl tellurium-based transporters in which their anion binding potency and anionophoric activity are controlled through reversible redox cycling between Te oxidation states. This unprecedented <i>in situ</i> reversible multistate switching allows f ...[more]

PMID: 36652378

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