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Vaccine effectiveness estimates from an early-season influenza A(H3N2) epidemic, including unique genetic diversity with reassortment, Canada, 2022/23.

ABSTRACT: The Canadian Sentinel Practitioner Surveillance Network estimated vaccine effectiveness (VE) during the unusually early 2022/23 influenza A(H3N2) epidemic. Like vaccine, circulating viruses were clade 3C.2a1b.2a.2, but with genetic diversity affecting haemagglutinin positions 135 and 156, and reassortment such that H156 viruses acquired neuraminidase from clade 3C.2a1b.1a. Vaccine provided substantial protection with A(H3N2) VE of 54% (95% CI: 38 to 66) overall. VE was similar against H156 and vaccine-like S156 viruses, but with potential variation based on diversity at position 135.

SUBMITTER: Skowronski DM

PROVIDER: S-EPMC9896608 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Vaccine effectiveness estimates from an early-season influenza A(H3N2) epidemic, including unique genetic diversity with reassortment, Canada, 2022/23.

Skowronski Danuta M DM Chuang Erica Sy ES Sabaiduc Suzana S Kaweski Samantha E SE Kim Shinhye S Dickinson James A JA Olsha Romy R Gubbay Jonathan B JB Zelyas Nathan N Charest Hugues H Bastien Nathalie N Jassem Agatha N AN De Serres Gaston G

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20230201 5

The Canadian Sentinel Practitioner Surveillance Network estimated vaccine effectiveness (VE) during the unusually early 2022/23 influenza A(H3N2) epidemic. Like vaccine, circulating viruses were clade 3C.2a1b.2a.2, but with genetic diversity affecting haemagglutinin positions 135 and 156, and reassortment such that H156 viruses acquired neuraminidase from clade 3C.2a1b.1a. Vaccine provided substantial protection with A(H3N2) VE of 54% (95% CI: 38 to 66) overall. VE was similar against H156 and v ...[more]

PMID: 36729117

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