IGF2BP3 overexpression predicts poor prognosis and correlates with immune infiltration in bladder cancer.

ABSTRACT:

Background

IGF2BP3 expression is associated with poor prognosis in cancers of multiple tissue origins. However, the precise mechanism of its co-carcinogenic action in bladder cancer is unknown.

Methods

We aimed to demonstrate the relationship between IGF2BP3 expression and pan-cancer using The Cancer Genome Atlas (TCGA) database. We next validated IGF2BP3 expression in the Gene Expression Omnibus (GEO) database (GSE3167). Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic values of IGF2BP3. Cox and logistic regression were used to explore the factors affecting the prognosis. Protein-protein interactions (PPIs) network was constructed by STRING. Enrichment analyses were performed to infer involved pathways and functional categories of I

SUBMITTER: Huang W 

PROVIDER: S-EPMC9896754 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature