Association of metformin exposure with low risks of frailty and adverse outcomes in patients with diabetes.

ABSTRACT:

Background

Diabetes is an independent risk factor of frailty, which increases adverse outcomes in patients with diabetes. Metformin is a common antidiabetic drug in clinical practice. Insulin resistance and chronic inflammation are the two common mechanisms of diabetes and frailty, as well as the main targets of metformin. Research suggested that metformin has anti-aging potential. However, few studies focus on the relationship between metformin and frailty. Thus, we aimed to explore whether metformin was associated with a low risk of frailty and other adverse outcomes in diabetic patients.

Methods

A total of 422 patients (≥ 40 years old) with type 2 diabetes were recruited. Frailty was defined by the Fried phenotype. General information and metformin exposure data were coll

SUBMITTER: Liu P 

PROVIDER: S-EPMC9896807 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature