Aluminum-based metal-organic framework nanoparticles as pulmonary vaccine adjuvants.

ABSTRACT: The adoption of pulmonary vaccines to advantageously provide superior local mucosal protection against aerosolized pathogens has been faced with numerous logistical and practical challenges. One of these persistent challenges is the lack of effective vaccine adjuvants that could be well tolerated through the inhaled route of administration. Despite its widespread use as a vaccine adjuvant, aluminum salts (alum) are not well tolerated in the lung. To address this issue, we evaluated the use of porous aluminum (Al)-based metal-organic framework (MOF) nanoparticles (NPs) as inhalable adjuvants. We evaluate a suite of Al-based MOF NPs alongside alum including DUT-4, DUT-5, MIL-53 (Al), and MIL-101-NH₂ (Al). As synthesized, MOF NPs ranged between ~ 200 nm and 1 µm in diameter, with

SUBMITTER: Stillman ZS 

PROVIDER: S-EPMC9896814 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature