Local Ugandan Production of Stable 0.2% Chlorhexidine Eye Drops.

ABSTRACT:

Purpose

The purpose of this study was to develop a protocol to prepare buffered chlorhexidine (CHX) eye drops (0.2% w/v) in the United Kingdom that can be reproduced at a production facility in Uganda. Buffered CHX eye drops can prevent CHX degradation and improve ocular tolerability during the treatment of fungal keratitis.

Methods

Buffered CHX eye drops in amber glass containers were prepared using sodium acetate buffer at pH 5.90 to 6.75. Two commercial CHX solutions and CHX in water were used as controls. Eye drops were stored at 40°C (70% humidity, 21 months) in the United Kingdom and at ambient temperature in Uganda (30 months). High-performance liquid chromatography was used to determine CHX stability over time, and pH was monitored. Sterility was achieved using an au

SUBMITTER: Picken CAR 

PROVIDER: S-EPMC9896845 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature