Repurposing of US-FDA approved drugs against SARS-CoV-2 main protease (M^pro) by using STD-NMR spectroscopy, in silico studies and antiviral assays.

ABSTRACT: SARS-CoV-2 Main protease (M^pro) is a well-known drug target against SARS-CoV-2 infection. Identification of M^pro inhibitors is vigorously pursued due to its crucial role in viral replication. The present study was aimed to identify M^pro inhibitors via repurposing of US-FDA approved drugs by STD-NMR spectroscopy. In this study, 156 drugs and natural compounds were evaluated against M^pro. Among them, 10 drugs were found to be interacting with M^pro, including diltiazem HCl (1), mefenamic acid (2), losartan potassium (3), mexiletine HCl (4), glaucine HBr (5), trimebutine maleate (6), flurbiprofen (7), amantadine HCl (8), dextromethorphan (9), and lobeline HCl (10) in STD-NMR spectroscopy. Their interactions were compared with three standar

SUBMITTER: Khan AM 

PROVIDER: S-EPMC9896891 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature