Signatures of muscle disuse in spaceflight and bed rest revealed by single muscle fiber proteomics.

ABSTRACT: Astronauts experience dramatic loss of muscle mass, decreased strength, and insulin resistance, despite performing daily intense physical exercise that would lead to muscle growth on Earth. Partially mimicking spaceflight, prolonged bed rest causes muscle atrophy, loss of force, and glucose intolerance. To unravel the underlying mechanisms, we employed highly sensitive single fiber proteomics to detail the molecular remodeling caused by unloading and inactivity during bed rest and changes of the muscle proteome of astronauts before and after a mission on the International Space Station. Muscle focal adhesions, involved in fiber-matrix interaction and insulin receptor stabilization, are prominently downregulated in both bed rest and spaceflight and restored upon reloading. Pathways of antio

SUBMITTER: Murgia M 

PROVIDER: S-EPMC9896895 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature