Modeling biological age and its link with the aging process

ABSTRACT: Abstract Differences in health status at older ages are a result of genetic predispositions and physiological responses to exposure accumulation over the lifespan. These vary across individuals and lead to health status heterogeneity as people age. Chronological age (CA) is a standard indicator that reflects overall risks of morbidity and mortality. However, CA is only a crude proxy for individuals’ latent physiological deterioration. An alternative to CA is biological age (BA), an indicator of accumulated age-related biological change reflected in markers of major physiological systems. We propose and validate two BA estimators that improve upon existing ones. These estimators (i) are based on a structural equation model (SEM) that represents the relation between BA and CA, (ii) circumven

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PROVIDER: S-EPMC9896935 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature