Shorter Cilia Length and Aberrant Ciliated Marker DNAI1 in Allergic Rhinitis.

ABSTRACT:

Purpose

This study aimed to investigate whether the impaired ciliary length and aberrant ciliary ultrastructure marker, dynein axonemal intermediate chain 1 (DNAI1), are important pathological characteristics in nasal mucosa from patients with allergic rhinitis (AR).

Patients and methods

Biopsies were taken from the inferior turbinate (IT) of controls (n = 20) and patients with AR (n = 20). The ciliary length and the DNAI1 location patterns were assessed by using immunofluorescent staining. Three patterns of DNAI1 localization were defined using a semi-quantitative scoring system: normal (N), partial (P) and absence (A). Every individual section was assigned a score between 0 and 2 in each high-power field (5 fields per sample). The score of 0 = pattern N >70%; 1 = patterns

SUBMITTER: Zhou S 

PROVIDER: S-EPMC9896970 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature