Blood transcriptome responses in patients correlate with severity of COVID-19 disease.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Infected individuals display a wide spectrum of disease severity, as defined by the World Health Organization (WHO). One of the main factors underlying this heterogeneity is the host immune response, with severe COVID-19 often associated with a hyperinflammatory state.

Aim

Our current study aimed to pinpoint the specific genes and pathways underlying differences in the disease spectrum and outcomes observed, through in-depth analyses of whole blood transcriptomics in a large cohort of COVID-19 participants.

Results

All WHO severity levels were well represented and mild and severe disease displaying distinct gene expression pro

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9896980 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature