Identification of key biomarkers and signaling pathways and analysis of their association with immune cells in immunoglobulin A nephropathy.

ABSTRACT:

Introduction

Immunoglobulin A nephropathy (IgAN) is the most common glomerular disease worldwide, with a poor prognosis. The aim of our study was to identify key biomarkers and their associations with immune cells to aid in the study of IgAN pathology and immunotherapy.

Material and methods

The data of IgAN were downloaded from a public database. The metaMA package and limma package were used to identify differentially expressed mRNAs (DEmRNAs) and differentially expressed miRNAs (DEmiRNAs), respectively. Biological functions of the DEmRNAs were analyzed. Machine learning was used to screen the mRNA biomarkers of IgAN. Pearson's correlation coefficient was used to analyze the correlation between mRNA biomarkers, immune cells and signaling pathways. Moreover, we constructed a

SUBMITTER: Zhang G 

PROVIDER: S-EPMC9896983 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature