A systematic review and meta-analysis of the association between HOTAIR polymorphisms and susceptibility to breast cancer.

ABSTRACT:

Introduction

Many studies are drawing attention to the associations of HOTAIR polymorphisms and susceptibility to breast cancer, while the results remain inconsistent. We conducted a meta-analysis on the association of four common HOTAIR polymorphisms with breast cancer susceptibility.

Material and methods

Eligible published articles were searched in PubMed, Embase, Cochrane library databases and Web of Science databases up to July 2019. Odds ratios with 95% confidence intervals were used to identify potential links between lncRNA HOTAIR polymorphisms and the risk of breast cancer.

Results

Our results showed no significance in all genetic models of all four SNPs. Pooled analyses detected crucial links between the rs1899663 polymorphism and decreased susceptibility to

SUBMITTER: Wang B 

PROVIDER: S-EPMC9897084 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature